Immunization with Tetanus Toxoid

Although immunization with tetanus toxoid cannot be expected to produce an adequate permanent immunity, a number of investigators have confirmed and extended the observation of Ramon3 to the effect that an organism, once immunized, will respond to further injections of toxoid with an accelerated and increased antitoxin production. That this response to the "injection de rappel" does occur has been adequately and clearly demonstrated, but it has not been entirely proved that this recall response takes place rapidly enough to provide effective protection against infection with tetanus. It was the purpose of this investigation to add to the available information on this point.